NFL Week 2 Odds: Daily Predictions and Lines

Week 2 of the 2026 NFL common season kicks off on Thursday, Sept. 17. The slate opens with Lions 41% (+144) vs. Bills 60% (-150) on Thursday Night Football in Buffalo. Sunday Night Football will see Colts 30% (+233) vs. Chiefs 71% (-245), with Giants 21% (+376) vs. Rams 80% (-400) closing the week on Monday Night Football.

Several divisional video games additionally spotlight the Week 2 slate, together with Panthers 52% (-108) vs. Falcons 50% (+100), Vikings 44% (+127) vs. Bears 57% (-133) and Commanders 31% (+223) vs. Cowboys 70% (-233). Here are the most recent Week 2 odds and predictions, pulled immediately from Kalshi and Polymarket US.

Week 2 matchups and opening strains

NFL Week 2 prediction market costs

Prices as of 4:02 p.m. ET on September 13, 2026

Week 2 odds and predictions

Detroit Lions @ Buffalo Bills | Thursday, Sept. 17 | 8:15 p.m. ET | Prime Video | Highmark Stadium, Orchard Park, NY |

Buffalo enters its residence opener as a 60% favourite, with Detroit at 41%. The early unfold has the Bills favored by greater than a area aim, whereas the over/beneath of 52.5 factors suggests the scoreboard might be energetic on Thursday night time. It’s a headline showdown for the primary short-week matchup of the season, that includes two potential contenders.

Carolina Panthers @ Atlanta Falcons | Sunday, Sept. 20 | 1 p.m. ET | FOX | Mercedes-Benz Stadium, Atlanta, GA |

The first NFC South sport on the Week 2 schedule can also be the tightest early moneyline. Carolina holds solely a 52% to 50% edge over Atlanta, leaving little separation between the division rivals. The market might react shortly as soon as we achieve extra readability on the Falcons QB scenario following a spate of accidents.

Cincinnati Bengals @ Houston Texans | Sunday, Sept. 20 | 1 p.m. ET | CBS | Reliant Stadium, Houston, TX |

Houston is a modest 55% favourite in an early matchup between two AFC groups with postseason expectations. Cincinnati sits at 47% in early pricing as they hit the highway for a stiff take a look at. The matchup pits what’s anticipated to be one of many league’s high passing assaults in opposition to the stout Houston protection.

Cleveland Browns @ Tampa Bay Buccaneers | Sunday, Sept. 20 | 1 p.m. ET | CBS | Raymond James Stadium, Tampa, FL |

Baker Mayfield is scheduled to face the franchise that chosen him first general within the 2018 NFL Draft. Tampa Bay is a transparent 75% favourite in opposition to Cleveland at 25%, one of many wider gaps on the Week 2 board. The matchup sees a Buccaneers group with postseason expectations welcoming a Browns squad waiting for higher days.

Green Bay Packers @ New York Jets | Sunday, Sept. 20 | 1 p.m. ET | FOX | MetLife Stadium, East Rutherford, NJ |

Green Bay is priced as a 69% highway favourite, whereas the Jets are at 33% for his or her residence opener. The Packers will journey to MetLife Stadium as one of many week’s bigger favorites regardless of enjoying on the highway. Green Bay enters the season with expectations of contending within the NFC, whereas the Jets will get an early take a look at in opposition to one of many convention’s extra full rosters.

Minnesota Vikings @ Chicago Bears | Sunday, Sept. 20 | 1 p.m. ET | FOX | Soldier Field, Chicago, IL |

Chicago holds a 57% to 44% edge on this NFC North matchup. The Week 2 assembly provides one other chapter to one of many NFL’s longstanding divisional rivalries, with the Bears getting the early-season matchup at Soldier Field. While early within the season, this one might carry some weight in what’s anticipated to be a aggressive NFC North chase.

New Orleans Saints @ Baltimore Ravens | Sunday, Sept. 20 | 1 p.m. ET | CBS | M&T Bank Stadium, Baltimore, MD |

Baltimore is an 81% favourite in opposition to New Orleans at 19%, giving the Ravens one of many strongest positions on the Week 2 menu. The matchup sends the Saints on the highway in opposition to a Baltimore group anticipated to once more contend close to the highest of the AFC. New Orleans can have its palms full making an attempt to gradual Lamar Jackson and a Ravens offense that presents matchup issues.

Philadelphia Eagles @ Tennessee Titans | Sunday, Sept. 20 | 1 p.m. ET | FOX | Nissan Stadium, Nashville, TN |

Philadelphia is among the stronger favorites on the Week 2 board at 76%, with Tennessee at 25% for its residence date with the Eagles. Protecting the quarterback is among the largest challenges for the Titans in opposition to a Philadelphia protection constructed to generate strain and disrupt opposing offenses. Tennessee might want to maintain up in opposition to that entrance to offer itself an opportunity in opposition to a possible NFC East contender.

Pittsburgh Steelers @ New England Patriots | Sunday, Sept. 20 | 1 p.m. ET | CBS | Gillette Stadium, Foxborough, MA |

New England is a 62% favourite regardless of opening the season with a 13-10 loss to Seattle. The Patriots will look to rebound at residence after struggling to generate offense within the opener, whereas Pittsburgh involves Foxborough for an early AFC matchup. New England’s potential to search out extra consistency offensively will likely be one of many key storylines heading into Week 2.

Jacksonville Jaguars @ Denver Broncos | Sunday, Sept. 20 | 4:05 p.m. ET | CBS | Empower Field at Mile High, Denver, CO |

Denver is a 55% favourite at residence, with Jacksonville at 46% in one of many extra aggressive non-divisional video games on the Week 2 board. The matchup brings collectively two groups seeking to set up themselves as playoff contenders within the AFC. Both reached the postseason final 12 months, with Jacksonville exiting within the Wild Card spherical and Denver advancing to the AFC Championship Game.

Las Vegas Raiders @ Los Angeles Chargers | Sunday, Sept. 20 | 4:05 p.m. ET | CBS | SoFi Stadium, Inglewood, CA |

The AFC West matchup pairs two reworked offenses, with Kirk Cousins and first-year head coach Klint Kubiak main Las Vegas whereas Justin Herbert adjusts to new Chargers offensive coordinator Mike McDaniel. Raiders tight finish Brock Bowers was dominated out of Week 1 with a knee damage. Los Angeles enters the matchup as a 71% favourite in an early divisional sport between longtime AFC West rivals.

Miami Dolphins @ San Francisco 49ers | Sunday, Sept. 20 | 4:25 p.m. ET | FOX | Levi’s Stadium, Santa Clara, CA |

Miami is starting a brand new period beneath head coach Jeff Hafley and quarterback Malik Willis, with six rookies listed as starters on the group’s first depth chart. San Francisco already has a division win after beating the Rams 27-7, whereas new receiver Mike Evans instantly gave Brock Purdy one other red-zone risk with six catches and a landing. The 49ers enter Week 2 because the strongest favourite on the board at 86%, organising a tough early take a look at for Miami’s new-look roster.

Seattle Seahawks @ Arizona Cardinals | Sunday, Sept. 20 | 4:25 p.m. ET | FOX | State Farm Stadium, Glendale, AZ |

Seattle enters this NFC West matchup 1-0 after rallying previous New England 13-10, however beginning quarterback Sam Darnold’s hip damage is an early Week 2 concern. Tests confirmed no fracture, with Drew Lock obtainable if Darnold is unable to play. Arizona begins the Mike LaFleur period with Jacoby Brissett put in as QB1, whereas Seattle enters the divisional matchup as a heavy 84% favourite.

Washington Commanders @ Dallas Cowboys | Sunday, Sept. 20 | 4:25 p.m. ET | FOX | AT&T Stadium, Arlington, TX |

This early NFC East assembly offers Jayden Daniels his first take a look at a rebuilt Dallas protection beneath first-year coordinator Christian Parker. The Cowboys are anticipated to stay with out standout left guard Tyler Smith, whose thumb damage carried a four-to-six-week restoration estimate coming into the season. Dallas remains to be a 70% favourite in opposition to Washington at 31% within the first of two conferences between the longtime division rivals.

Indianapolis Colts @ Kansas City Chiefs | Sunday, Sept. 20 | 8:20 p.m. ET | NBC | GEHA Field at Arrowhead Stadium, Kansas City, MO |

Both beginning quarterbacks are getting back from main 2025 accidents, with Daniel Jones again from a torn Achilles and Patrick Mahomes getting back from a torn ACL. Both had been cleared for the beginning of the season, including one other layer to an early AFC matchup between two veteran quarterbacks. Kansas City additionally added reigning Super Bowl MVP Kenneth Walker III to its backfield and enters Week 2 as a 71% favourite in opposition to Indianapolis at 30%.

New York Giants @ Los Angeles Rams | Monday, Sept. 21 | 8:15 p.m. ET | ESPN/ABC | SoFi Stadium, Inglewood, CA |

The Rams return residence seeking to reply after a 27-7 opening loss to San Francisco in Melbourne. Whether Aaron Donald makes his return from retirement in opposition to New York stays a serious storyline after Sean McVay held him out of Week 1 and mentioned he must be prepared “sooner slightly than later.” The Giants start a brand new chapter beneath John Harbaugh and second-year quarterback Jaxson Dart, whereas Los Angeles enters the matchup as a heavy 80% favourite.

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